In 52 BC, following the massacre of Roman citizens living in Cenabum (Orléans) by the Carnutes, the Arvernian Vercingetorix won several of the Gaulish tribes to his revolutionary cause and marched in person to the lands of the Biturige. The Biturige sent ambassadors to the powerful Aedui tribe, with whom they had an alliance, to solicit aid and protection. The Aeduan horse and foot brigades arrived at the Loire but, fearing a trap, didn't enter the Biturige territory. After their departure, the Biturige immediately aligned themselves with the Arverni.

Caesar, learning of these developments, gathered together the bulk of the Roman army, marched to Cenabum and from there entered the lands of the Biturige. He took Noviodunum before marching on and laying siege to Avaricum, the capital. Following his defeats, Vercingetorix, changing strategy, advised a scorched earth policy before the advancing Roman legions.

In the months of March and April 52 BC, in appalling weather conditions, the siege of the capital took place. Despite the valour of the Bituriges warriors, Avaricum was taken and sacked.

Some months later, after the battle of Gergovia, Vercingetorix sought refuge in Alesia. In an attempt to lift Caesar's subsequent siege of the oppidum, a Gaulish rescue force, including 12,000 Bituriges warriors, was raised but, after a devastating battle, the city fell and Vercingetorix was handed over to Caesar.

In 51 BC, a suspicious Caesar sent the 13th legion to make its winter quarters in the eastern part of the Biturige territory. Attempting to profit from the bad weather, the chieftains of the Biturige gathered their forces and prepared their men for combat once more. However, Caesar mounted a surprise campaign at the head of the 13th legion and reinforced by the 11th legion which had been stationed nearby, and forced the Biturige into suing for peace.

Benefitting from the clemency of Caesar, the Biturige submitted to Roman domination and, when the Carnutes attacked from the north, were quick to call on the Roman army for assistance.

Thus it was that the Biturige became subjects of Rome.