After the Gallo-Roman town of Argentomagus was abandoned, little is known of the history of Saint-Marcel until the 12th century.

At the end of the 12th century, after Philippe Augustre recaptured it from the English, the town of Argenton was called Cappalanus Sancti Marcelli.

In the year 1200, the marriage of Blanche of Castille to Louis of France reunited the fiefdoms of the Berry to the kingdom of France, and, through this influence, in 1285 stewardship of the town passed into the hands of the church.

During the 100 years war, the Berry was exposed to the full vicissitudes of war and the last remains were destroyed.

The 15th century was marked by the construction of many buildings which are no longer standing today and by a number of conflicts between the lords of Argenton and the priors of Saint-Marcel over justice in the town.

The ramparts of Saint-Marcel were taken by the "Ligueurs" in 1591, and Henri IV in 1589 began the conquest of his kingdom with the taking of Argenton.

Despite the conflicts, the religious wars and the plague, for Saint-Marcel the 16th century was synonymous with prosperity and "renaissance".

The period of the revolution, however, removed many testaments to the area's rich history.